Extract to any folder. You should get a folder called "esetupd" along with the update files inside.
Move that folder to the C:. (You should have"c:esetupd")
Open up the NOD32 Control Center by clicking on the system tray icon.
Open the "Update" screen and click on "Setup"
In the "Server" dropdown list, choose the last item which should point to C:esetupd.
Click OK to close the update setup window.
Back at the update screen, click "Update now"

http://hotfile.com/dl/27852279/478097a/nupdate4842.rar